Uppsala University Behavioral Facility (UUBF)

Welcome to Uppsala University Behavioral Facility (UUBF), a platform for behavioral testing of mouse, rat and fish. We have long experience in working with behavioral studies and can provide expertise in this field.

The aim of this behavioral facility is to provide help to research groups at Uppsala University as well as others, with the performance and interpretation of behavioral studies including mouse, rat and fish. The researchers working at UUBF have extensive experience within different areas of experimental animal behaviors studies. At our behavioral facility there are equipment for assessment of different kinds of behaviors, where some of the equipment can be moved outside the facility. For most of the tests protocols (SOPs) are available. If you have any questions about how to design your studies you are welcome to contact us. We can also provide help with animal ethical applications as well as with statistical analyzes and inerpretation of data from performed studies.

UUBF is a non-profit core facility, part of the technology platforms supported by strategic funding by the Faculty of Medicine and Pharmacy. The facility was established in 2011. We have close collaboration with the University veterinarians and aim to refine methods used and reduce the number of animals used in studies.

We look forward to help you with your behavioral studies!

Please contact us at uubf@farmbio.uu.se

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News:

Examples of ongoing projects at UUBF:

Analysis of fish behavior:

Analysis of fish behavioral recordings using the Ethovision XT program (Noldus Information Technology). Using the Ethovision software the behavior of the fish, like velocity and distance moved in the test arena, can be analyzed.

A multivariate test arena is being evaluated in which a behavioral profile of the fish can be obtained. The arena consists of several different environments, such as sheltered and open areas. With this test behavioral profiles can be determined without using a test battery and thereby handling-induced and cross-over effects.

Analysis of motoric and non-motoric symptoms in Parkinson´s disease:

Different tests for measurement of muscle strength and fine motoric movements as well as more complex behaviors are used to analyze motoric symptoms and behavioral profiles in a transgenic mouse model for Parkinson´s disease.

Handling of animals to avoid stress in experiments:

In order to avoid handling-induced side effects in behavioral studies, it is important to habituate the animals prior to the experiments. UUBF can provide with protocols for handling of rats and mice and can show you various handling procedures.

Course Evaluation - “How to study behavior in vertebrates with focus on fish and rodents” Spring 2017

Here you find the course evaluation for the course that was given spring 2017

Survey UUBF 2015

Here you can read the summary of the questionnaire sent out autumn of 2015. Survey 2015.

New publications

Identification of a Neuronal Receptor Controlling Anaphylaxis. fRogoz K, Aresh B, Freitag FB, Pettersson H, Magnúsdóttir EI, Larsson Ingwall L, Haddadi Andersen H, Franck MC, Nagaraja C, Kullander K, Lagerström MC.Cell Rep. 2015.

SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis.
Larhammar M, Patra K, Blunder M, Emilsson L, Peuckert C, Arvidsson E, Rönnlund D, Preobraschenski J, Birgner C, Limbach C, Widengren J, Blom H, Jahn R, Wallén-Mackenzie Å, Kullander K.
Biol Psychiatry. 2015.

Risk-assessment and risk-taking behavior predict potassium- and amphetamine-induced dopamine response in the dorsal striatum of rats. Palm S, Momeni S, Lundberg S, Nylander I, Roman E. Frontiers in Behavioral Neuroscience. 2014. 

A Rank-Order Procedure Applied to an Ethexperimental Behavior Model -The Multivariate Concentric Square FieldTM (MCSF) Test. Meyerson BJ, Jurek B, Roman E. Journal of Behavioral and Brain Science. 2013.

Diffuse traumatic axonal injury in mice induces complex behavioral alterations that are normalized by neutralization of interleukin- 1β. Ekmark-Lewén S, Flygt J, Fridgeirsdottir G, Kiwanuka O, Hånell A, Meyerson BJ, Mir AK, Gram H, Lewén A, Clausen F, Hillered L, Marklund N. EJN accepted for publication Jan 2016.