Senaste publikationer

  • Artikel, forskningsöversikt

    Hens, Bart; Augustijns, Patrick; Lennernäs, Hans; McAllister, Mark et al.

    Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

    Ingår i Frontiers in Medicine, 2021.

    Open access
  • Artikel i tidskrift

    Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian et al.

    ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

    Ingår i Molecular Pharmaceutics, s. 361-372, 2020.

  • Artikel i tidskrift

    Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

    The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

    Ingår i Pharmaceutics, 2020.

    Open access
  • Artikel, forskningsöversikt

    Keutzer, Lina; Wicha, Sebastian G.; Simonsson, Ulrika S H

    Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review

    Ingår i JMIR mhealth and uhealth, 2020.

  • Artikel i tidskrift

    Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael et al.

    Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

    Ingår i Pharmaceutics, 2020.

    Open access
  • Artikel i tidskrift

    Faraj, Alan; Svensson, Robin J.; Diacon, Andreas H.; Simonsson, Ulrika S H

    Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients

    Ingår i Antimicrobial Agents and Chemotherapy, 2020.

    Open access
  • Artikel i tidskrift

    Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

    Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

    Ingår i Applied Sciences, 2020.

    Open access
  • Artikel i tidskrift

    Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P. et al.

    Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

    Ingår i European journal of pharmaceutics and biopharmaceutics, s. 236-247, 2020.

  • Artikel i tidskrift

    Keutzer, Lina; Simonsson, Ulrika S. H.

    Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing: Using Rifampicin as an Example

    Ingår i Frontiers in Pharmacology, 2020.

    Open access
  • Artikel, forskningsöversikt

    Dahlgren, David; Lennernäs, Hans

    Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

    Ingår i Molecules, 2020.

    Open access
  • Artikel i tidskrift

    Gupta, Neeraj; Bottino, Dean; Simonsson, Ulrika S H; Musante, Cynthia J. et al.

    Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development

    Ingår i Clinical Pharmacology and Therapeutics, s. 1285-1289, 2020.

  • Artikel i tidskrift

    Faraj, Alan; Clewe, Oskar; Svensson, Robin J.; Mukamolova, Galina V. et al.

    Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions

    Ingår i Scientific Reports, 2020.

    Open access
  • Artikel, forskningsöversikt

    Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

    Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

    Ingår i ADMET & DMPK, s. 375-390, 2020.

    Open access
  • Artikel i tidskrift

    Dahlgren, David; Cano-Cebrian, Maria-Jose; Hellström, Per M.; Wanders, Alkwin et al.

    Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

    Ingår i International Journal of Molecular Sciences, 2020.

    Open access
  • Artikel i tidskrift

    Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran et al.

    Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

    Ingår i Obesity Science & Practice, s. 313-323, 2020.

    Open access
  • Artikel i tidskrift

    Augustijns, Patrick; Vertzoni, Maria; Reppas, Christos; Langguth, Peter et al.

    Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications

    Ingår i European Journal of Pharmaceutical Sciences, 2020.

    Open access
  • Artikel i tidskrift

    Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

    Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

    Ingår i European journal of pharmaceutics and biopharmaceutics, s. 191-202, 2020.

  • Artikel i tidskrift

    Susanto, Budi O.; Wicha, Sebastian G; Hu, Yanmin; Coates, Anthony R M et al.

    Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development.

    Ingår i Clinical Pharmacology and Therapeutics, s. 274-286, 2020.

    Open access
  • Artikel i tidskrift

    Davies Forsman, Lina; Niward, Katarina; Kuhlin, Johanna; Zheng, Xubin et al.

    Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

    Ingår i European Respiratory Journal, 2020.

  • Artikel i tidskrift

    Clewe, Oskar; Faraj, Alan; Hu, Yanmin; Coates, Anthony R M et al.

    A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.

    Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 421-430, 2020.

  • Artikel i tidskrift

    Van Wijk, Rob C.; van der Sar, Astrid M.; Krekels, Elke H. J.; Verboom, Theo et al.

    Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development

    Ingår i Clinical and Translational Science, s. 1060-1064, 2020.

    Open access
  • Artikel i tidskrift

    Van Wijk, Rob C.; Hu, Wanbin; Dijkema, Sharka M.; Van den Berg, Dirk-Jan et al.

    Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans

    Ingår i British Journal of Pharmacology, s. 5518-5533, 2020.

    Open access
  • Artikel i tidskrift

    Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

    Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

    Ingår i AAPS Journal, 2020.

    Open access
  • Artikel i tidskrift

    Susanto, Budi Octasari; Svensson, Robin J.; Svensson, Elin M.; Aarnoutse, Rob et al.

    Rifampicin can be given as flat-dosing instead of weight-band dosing

    Ingår i Clinical Infectious Diseases, s. 3055-3060, 2020.

    Open access
  • Artikel i tidskrift

    Keutzer, Lina; Simonsson, Ulrika S. H.

    Medical Device Apps: An Introduction to Regulatory Affairs for Developers

    Ingår i JMIR mhealth and uhealth, 2020.

    Open access
  • Artikel i tidskrift

    Selch Larsen, Malte; Vestergaard Juul, Rasmus; Zintner, Shannon M.; Kristensen, Annemarie T. et al.

    Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene-based FVIIa prophylaxis

    Ingår i Haemophilia, s. 164-172, 2020.

  • Artikel, forskningsöversikt

    Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z et al.

    The Critical Role of Passive Permeability in Designing Successful Drugs

    Ingår i ChemMedChem, s. 1862-1874, 2020.

    Open access
  • Artikel i tidskrift

    Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa; Ericsson, Hans et al.

    Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

    Ingår i Drug Metabolism and Pharmacokinetics, s. S70-S71, 2019.

  • Artikel, forskningsöversikt

    Dahlgren, David; Lennernäs, Hans

    Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

    Ingår i Pharmaceutics, 2019.

    Open access
  • Artikel i tidskrift

    Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik et al.

    Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

    Ingår i Journal of Drug Delivery Science and Technology, 2019.

    Open access
  • Artikel i tidskrift

    Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik et al.

    Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

    Ingår i Cancers, 2019.

    Open access
  • Artikel i tidskrift

    Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

    Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

    Ingår i European journal of pharmaceutics and biopharmaceutics, s. 411-420, 2019.

  • Artikel i tidskrift

    Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

    Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

    Ingår i European journal of pharmaceutics and biopharmaceutics, s. 387-395, 2019.

  • Artikel i tidskrift

    Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

    Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

    Ingår i European journal of pharmaceutics and biopharmaceutics, s. 31-37, 2019.

  • Artikel i tidskrift

    Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

    Rat intestinal drug permeability: A status report and summary of repeated determinations

    Ingår i European journal of pharmaceutics and biopharmaceutics, s. 364-376, 2019.

  • Artikel i tidskrift

    Svensson, Robin J.; Niward, Katarina; Davies Forsman, Lina; Bruchfeld, Judith et al.

    Individualised dosing algorithm and personalised treatment of high‐dose rifampicin for tuberculosis

    Ingår i British Journal of Clinical Pharmacology, s. 2341-2350, 2019.

  • Artikel i tidskrift

    Svensson, Robin J.; Sabiiti, Wilber; Kibiki, Gibson S.; Ntinginya, Nyanda E. et al.

    Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture

    Ingår i Antimicrobial Agents and Chemotherapy, 2019.

  • Artikel i tidskrift

    Wyatt, David; Strauss, David; Ray, Balmiki; Mehta, Krina et al.

    Consider ASCPT in Your End-of-Year Giving

    Ingår i Clinical Pharmacology and Therapeutics, s. 17-21, 2019.

  • Artikel i tidskrift

    Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa et al.

    Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

    Ingår i Molecular Pharmaceutics, s. 3053-3064, 2019.

  • Artikel i tidskrift

    Dubbelboer, Ilse R; Lilienberg, Elsa; Karalli, Amar; Axelsson, Rimma et al.

    Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

    Ingår i Molecular Pharmaceutics, s. 336-340, 2018.

  • Artikel i tidskrift

    Eriksson, Johanna; Sjögren, Erik; Thörn, Helena; Rubin, Katarina et al.

    Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

    Ingår i European journal of pharmaceutics and biopharmaceutics, s. 1-12, 2018.

  • Artikel i tidskrift

    Larsen, Malte Selch; Juul, Rasmus Vestergaard; Groth, Andreas Velsing; Simonsson, Ulrika S H et al.

    Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

    Ingår i European Journal of Pharmaceutical Sciences, s. 196-203, 2018.

  • Artikel i tidskrift

    Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

    The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

    Ingår i International Journal of Pharmaceutics, s. 158-168, 2018.

  • Artikel i tidskrift

    Larsen, Malte Selch; Juul, Rasmus Vestergaard; Kreilgaard, Mads; Kristensen, Annemarie T. et al.

    Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors

    Ingår i European Journal of Pharmaceutical Sciences, s. 531-538, 2018.

  • Artikel i tidskrift

    Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

    Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

    Ingår i International Journal of Pharmaceutics, s. 239-248, 2018.

  • Artikel i tidskrift

    Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

    Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

    Ingår i AAPS Journal, 2018.

    Open access
  • Artikel, forskningsöversikt

    Hens, Bart; Sinko, Patrick D.; Job, Nicholas; Dean, Meagan et al.

    Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

    Ingår i International Journal of Pharmaceutics, s. 120-127, 2018.

  • Artikel i tidskrift

    Hens, Bart; Al-Gousous, Jozef; Wang, Kai; Salehi, Niloufar et al.

    Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018

    Ingår i DISSOLUTION TECHNOLOGIES, s. 50 50-53 53, 2018.

  • Artikel i tidskrift

    Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa P.; Ericsson, Hans et al.

    Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

    Ingår i Drug Metabolism And Disposition, s. 1420-1433, 2018.

  • Artikel i tidskrift

    Wicha, Sebastian G.; Clewe, Oskar; Svensson, Robin J.; Gillespie, Stephen H. et al.

    Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin

    Ingår i Clinical Pharmacology and Therapeutics, s. 1208-1218, 2018.

    Open access