Spatial Mass Spectrometry’
This National Center for Mass Spectrometry Imaging (NCMSI) resource was founded at the Uppsala University in 2010 with funds provided by the Swedish Research Council-Research Infrastructure (VR-RFI) in 2010 (grant 2009-6050) and Uppsala University-Infrastructure in 2013.
The mission of the Center is to accelerate the adoption of the MALDI (matrix-assisted laser desorption ionization)-MSI technology to the biological, pharmaceutical and medical research communities by providing access to advanced technologies and promoting interactions between scientists who are experts in these technologies and researchers conducting focused biological investigations. Such collaborations provide new insights into targeted biological problems and a better understanding of health and disease at the molecular level. As part of this mission, Center scientists will share their knowledge and experience with workers new to MSI and the wider scientific community so that they may better benefit from the technology.
The National Center for Mass Spectrometry Imaging (NCMSI) is divided in several nodes. The Uppsala University MALDI-MSI laboratory was one of the first established in Europe (first in Scandinavia), and was funded by K&A Wallenberg Foundation in 2004. A second MSI node in Göteborg, focusing on SIMS (Secondary Ion Mass Spectrometry)-MSI, high-spatial resolution imaging of lipids and endogenous metabolites is headed by Prof. Andrew Ewing at Chalmers and Gothenburg University. This laboratory was awarded a VR-RFI status in 2013 (The National Center for Imaging Mass Spectrometry at Chalmers and Gothenburg University). The two national imaging laboratories are therefore complementary to each other. The Uppsala node has a good collaboration with the Chalmers and Gothenburg node lead by Prof. Ewing.
Another important activity of the NCMSI is training, informing scientists about the capabilities and limitations of the technology, good practices, and to establish methods and protocols. Proposed training activities include one-on-one interactions with visiting scientists, long-term visits of one or more scientists from specific laboratories, a yearly formal course at the Center.
NCMSI uses state-of-the art mass spectrometry technologies and cutting edge research to help projects in e.g., Drug Discovery and Development, Neuroscience, Oncology and Pathology applications.
NCMSI is located in Dr. Per Andrén´s research group at the Faculty of Pharmacy, Uppsala University, Uppsala, Sweden.
NCMSI objective is to provide collaboration resources and support to:
1) academic research groups
2) pharmaceutical biotech and big-pharma companies.
Collaborations with the NCMSI resource are initiated by submission of a brief research plan. The Advisory Committee, comprised of senior faculty within the NCMSI platform, will review these plans with regard to the appropriateness of MSI to solve the proposed problem, funding source, and the availability of resources to perform the proposed work.