Publications

Stage, Tore Bjerregaard; Wellhagen, Gustaf; Christensen, Mette Marie Hougaard; Guiastrennec, Benjamin et al.

Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics

Part of Basic & Clinical Pharmacology & Toxicology, p. 105-114, 2019.

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Ibrahim, Moustafa M. A.

Pharmacometric evaluation and improvement of models and study designs - applied in diabetes

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Wyatt, David; Strauss, David; Ray, Balmiki; Mehta, Krina et al.

Consider ASCPT in Your End-of-Year Giving

Part of Clinical Pharmacology and Therapeutics, p. 17-21, 2019.

To DiVA

Zelleroth, Sofia; Nylander, Erik; Nyberg, Fred; Grönbladh, Alfhild et al.

Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures

Part of Neuroscience, p. 172-183, 2019.

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Thörnqvist, Per-Ove; McCarrick, Sarah; Ericsson, Maja; Roman, Erika et al.

Bold zebrafish (Danio rerio) express higher levels of delta opioid and dopamine D2 receptors in the brain compared to shy fish

Part of Behavioural Brain Research, p. 927-934, 2019.

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Sou, Tomás; Kukavica-Ibrulj, Irena; Soukarieh, Fadi; Halliday, Nigel et al.

Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

Part of Journal of Pharmaceutical Sciences, p. 630-640, 2019.

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Ibarra, Cristian; Karlsson, Marie; Codeluppi, Simone; Varas-Godoy, Manuel et al.

BCG-induced cytokine release in bladder cancer cells is regulated by Ca2+ signaling

Part of Molecular Oncology, p. 202-211, 2019.

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Schou, Magnus; Ewing, Par; Cselenyi, Zsolt; Fridén, Markus et al.

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

Part of EJNMMI Research, 2019.

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Titova, Olga E.

Metabolic Health and Cognitive Function: The Roles of Lifestyle and Shift Work

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Kempen, Thomas; Hedström, Mariann; Olsson, Hanna; Johansson, Amanda et al.

Assessment tool for hospital admissions related to medications: development and validation in older patients

Part of International Journal of Clinical Pharmacy, p. 198-206, 2019.

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Thorsted, Anders; Bouchene, Salim; Tano, Eva; Castegren, Markus et al.

A non-linear mixed effect model for innate immune response: In vivo kinetics of endotoxin and its induction of the cytokines tumor necrosis factor alpha and interleukin-6

Part of PLoS ONE, 2019.

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Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R.; Antoni, Gunnar et al.

High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

Part of NeuroImage, p. 881-888, 2019.

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Kempen, Thomas; Kälvemark, A.; Gillespie, Ulrika; Stewart, D.

Comprehensive medication reviews in Swedish hospitals: what does the patient have to say?

Part of International Journal of Clinical Pharmacy, p. 346-346, 2019.

To DiVA

Duthaler, Urs; Suenderhauf, Claudia; Karlsson, Mats O; Hussner, Janine et al.

Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers

Part of British Journal of Clinical Pharmacology, p. 626-633, 2019.

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Ibrahim, Moustafa M. A.; Ueckert, Sebastian; Freiberga, Svetlana; Kjellsson, Maria C. et al.

Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment

Part of AAPS Journal, 2019.

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Ibrahim, Moustafa M. A.; Nordgren, Rikard; Kjellsson, Maria C.; Karlsson, Mats O.

Variability Attribution for Automated Model Building

Part of AAPS Journal, 2019.

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Wu, Chi-Chih; Klaesson, Axel; Buskas, Julia; Ranefall, Petter et al.

In situ quantification of individual mRNA transcripts in melanocytes discloses gene regulation of relevance to speciation

Part of Journal of Experimental Biology, 2019.

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Ho, Ada M-C; Geske, Jennifer R.; Bakalkin, Georgy; Winham, Stacey J. et al.

Correlations between sex-related hormones, alcohol dependence and alcohol craving

Part of Drug And Alcohol Dependence, p. 183-190, 2019.

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Lundberg, Stina; Högman, Cecilia; Roman, Erika

Adolescent Exploratory Strategies and Behavioral Types in the Multivariate Concentric Square Field (TM) Test

Part of Frontiers in Behavioral Neuroscience, 2019.

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Herman, Stephanie; Åkerfeldt, Torbjörn; Spjuth, Ola; Burman, Joachim et al.

Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing-Remitting Multiple Sclerosis

Part of Cells, 2019.

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Ryeznik, Yevgen

Optimal adaptive designs and adaptive randomization techniques for clinical trials

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Isaksson, Rebecka; Lindman, Jens; Wannberg, Johan; Sallander, Jessica et al.

A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Part of ChemistryOpen, p. 114-125, 2019.

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Tay, Nicole; Macare, Christine; Liu, Yun; Ruggeri, Barbara et al.

Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse

Part of American Journal of Psychiatry, p. 146-155, 2019.

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Zetterström, Andreas; Hämäläinen, Markku D.; Karlberg, Elin; Winkvist, Maria et al.

Maximum Time Between Tests: A Digital Biomarker to Detect Therapy Compliance and Assess Schedule Quality in Measurement-Based eHealth Systems for Alcohol Use Disorder

Part of Alcohol and Alcoholism, p. 70-72, 2019.

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Toxopeus, Eelke L. A.; de Man, Femke M.; Krak, Nanda; Biermann, Katharina et al.

Association between Paclitaxel Clearance and Tumor Response in Patients with Esophageal Cancer

Part of Cancers, 2019.

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Ruth, Mike Marvin; Sangen, Jasper J. N.; Remmers, Karlijn; Pennings, Lian J. et al.

A bedaquiline/clofazimine combination regimen might add activity to the treatment of clinically relevant non-tuberculous mycobacteria

Part of Journal of Antimicrobial Chemotherapy, p. 935-943, 2019.

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Germovsek, Eva; Osborne, Leanne; Gunaratnam, Flora; Lounis, Shehrazed A. et al.

Development and external evaluation of a population pharmacokinetic model for continuous and intermittent administration of vancomycin in neonates and infants using prospectively collected data

Part of Journal of Antimicrobial Chemotherapy, p. 1003-1011, 2019.

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Brekkan, Ari; Lopez-Lazaro, Luis; Plan, Elodie L.; Nyberg, Joakim et al.

Pharmacokinetic and Pharmacodynamic Sensitivity of Pegfilgrastim

Part of AAPS Journal, 2019.

To DiVA

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Part of Scientific Reports, 2019.

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Kinch, Amelie; Sundström, Christer; Baecklund, Eva; Backlin, Carin et al.

Expression of PD-1, PD-L1, and PD-L2 in posttransplant lymphoproliferative disorder after solid organ transplantation

Part of Leukemia and Lymphoma, p. 376-384, 2019.

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Svensson, Robin J.

Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

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Kensert, Alexander; Harrison, Philip J; Spjuth, Ola

Transfer Learning with Deep Convolutional Neural Networks for Classifying Cellular Morphological Changes

Part of SLAS discovery : advancing life sciences R & D, p. 466 466-475 475, 2019.

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Ibrahim, Moustafa M. A.; Largajolli, Anna; Kjellsson, Maria C.; Karlsson, Mats

Translation between two models; Application with integrated glucose homeostasis models

Part of Pharmaceutical research, 2019.

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Kononenko, Olga; Watanabe, Hiroyuki; Stålhandske, Lada; Zarelius, Ann et al.

Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

Part of Restorative Neurology and Neuroscience, p. 87-96, 2019.

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Peters, Kristian; Bradbury, James; Bergmann, Sven; Capuccini, Marco et al.

PhenoMeNal: Processing and analysis of metabolomics data in the cloud

Part of GigaScience, 2019.

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Germovsek, Eva; Ambery, Claire; Yang, Shuying; Beerahee, Misba et al.

A Novel Method for Analysing Frequent Observations from Questionnaires in Order to Model Patient-Reported Outcomes: Application to EXACT (R) Daily Diary Data from COPD Patients

Part of AAPS Journal, 2019.

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Maarbjerg, Sabine F.; Thorsted, Anders; Kristoffersson, Anders; Friberg, Lena E. et al.

Piperacillin pharmacokinetics and target attainment in children with cancer and fever: Can we optimize our dosing strategy?

Part of Pediatric Blood & Cancer, 2019.

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van Beek, Stijn W.; ter Heine, Rob; Keizer, Ron J.; Magis-Escurra, Cecile et al.

Personalized Tuberculosis Treatment Through Model-Informed Dosing of Rifampicin

Part of Clinical Pharmacokinetics, p. 815-826, 2019.

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Jernerén, Fredrik; Cederholm, Tommy; Refsum, Helga; Smith, A. David et al.

Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study

Part of Journal of Alzheimer's Disease, p. 189-197, 2019.

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Ibrahim, Moustafa M. A.; Largajolli, Anna; Karlsson, Mats; Kjellsson, Maria C.

The Integrated Glucose Insulin Minimal Model: An improved version

Part of European Journal of Pharmaceutical Sciences, p. 7-19, 2019.

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Heldin, Johan; Rubin Sander, Marie; Leino, Mattias; Thomsson, Sara et al.

Dynamin inhibitors impair platelet-derived growth factor beta-receptor dimerization and signaling

Part of Experimental Cell Research, p. 69-79, 2019.

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Abrantes, João A.

Pharmacometric Approaches to Improve Dose Individualization Methods in Hemophilia A

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Brekkan, Ari

Pharmacometric models in the development of biological medicinal products

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Lampa, Samuel; Dahlö, Martin; Alvarsson, Jonathan; Spjuth, Ola

SciPipe-Turning Scientific Workflows into Computer Programs

Part of Computing in science & engineering (Print), p. 109-113, 2019.

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Hu, Yang; Gaillard, Pieter J.; De lange, Elizabeth C.M.; Hammarlund-Udenaes, Margareta

Targeted Brain Delivery of Methotrexate by Glutathione PEGylated Liposomes: How can the Formulation Make a Difference?

Part of European journal of pharmaceutics and biopharmaceutics, p. 197-204, 2019.

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Arshad, Usman; Chasseloup, Estelle; Nordgren, Rikard; Karlsson, Mats O.

Development of visual predictive checks accounting for multimodal parameter distributions in mixture models

Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 241-250, 2019.

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Atis, Muge; Akcan, Ugur; Ugur Yilmaz, Canan; Orhan, Nurcan et al.

Effects of methyl-beta-cyclodextrin on blood-brain barrier permeability in angiotensin II-induced hypertensive rats

Part of Brain Research, p. 148-155, 2019.

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Dhillon, Sundeep S.; Torell, Frida; Donten, Magdalena; Lundstedt-Enkel, Katrin et al.

Metabolic profiling of zebrafish embryo development from blastula period to early larval stages

Part of PLoS ONE, 2019.

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Abrantes, João A.; Jönsson, Siv; Karlsson, Mats; Nielsen, Elisabet I.

Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data

Part of British Journal of Clinical Pharmacology, p. 1326-1336, 2019.

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Kurland, Siri; Furebring, Mia; Löwdin, Elisabeth; Eliasson, E. et al.

Pharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels

Part of Antimicrobial Agents and Chemotherapy, 2019.

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