Protein drug design

Front: Aikaterini Chourlia, IsakSofia Stenler, Canan Ugur Yilmaz,
Ulrika Linde, Neira Babic
Middle: Jamie Morrison, Greta Hultqvist,
Nicole Metzendorf, Fadi Rofo, Inga Peterson
Back: Andrés De La Rosa, Antonino Napoleone
 

Immunotherapy is one of the fastest growing fields within drug development. The antibodies that are used and cannot pass cell membranes or the blood-brain barrier (BBB). Hence, they can only reach easily accessible targets unless they are modified. The goal with our research is to open up possibilities to reach new goals. We design and evaluate multispecific antibodies, where some parts bind to the things one wants to modify or detect in a disease and other parts acts as transporters to bring the antibody to its target.

Figure 1. A schematic picture of how the transport across the
BBB takes place. An antibody with BBB transporter. How the
transporters are connected to the antibody is important for its function. 
Figure 2. An antibody with blood-brain barrier transporters. How the
transporters are connected to the antibody is important for its function.
A schematic picture of how the transport across the BBB takes place.